9TWV

Complex of E. coli leucyl-tRNA synthetase AN3365-resistant mutant D345A bound to tRNA(leu)

This is a non-PDB format compatible entry.

Summary for 9TWV

• Entry DOI: 10.2210/pdb9twv/pdb
• Descriptor: Leucine--tRNA ligase, tRNA(leu), (2~{S})-2-azanyl-~{N}-[azanyl-(3-fluorophenyl)-oxidanylidene-$l^{6}-sulfanylidene]-4-methyl-pentanamide, ... (6 entities in total)
• Functional Keywords: leucine trna ligase antimicrobial target resistant mutant epetraborole, rna binding protein
• Biological source: Escherichia coli; More
• Total number of polymer chains: 2
• Total formula weight: 127942.44

Authors

Hoffmann, G.,Palencia, A.,Muller, B. (deposition date: 2026-01-15, release date: 2026-09-02)

• Primary citation: Muller, B.,Fries, F.,Huber, A.L.,Risch, T.,Mohamadyar-Toupkanlou, F.,Hoffmann, G.,Dulic, M.,Herrmann, J.,Guic Sovulj, I.,Muller, R.,Palencia, A.; Mechanisms of Resistance to an Antibiotic Targeting Bacterial Leucyl-tRNA Synthetase; Nat Commun, 2026

Experimental method

X-RAY DIFFRACTION (2.111 Å)