9TJV

Ternary complex of E. coli leucyl-tRNA synthetase mutant W177A, tRNA(leu) and the leucyl adenylate analog LeuAMS in the aminoacyl transfer state

Summary for 9TJV

Entry DOI	10.2210/pdb9tjv/pdb
Descriptor	Leucine--tRNA ligase, tRNA(leu), 5'-O-(L-leucylsulfamoyl)adenosine, ... (5 entities in total)
Functional Keywords	leucine trna ligase antimicrobial target trna aminoacylation for protein translation, rna binding protein
Biological source	Escherichia coli More
Total number of polymer chains	4
Total formula weight	255874.63
Authors	Hoffmann, G.,Palencia, A. (deposition date: 2025-12-08, release date: 2026-08-05)
Primary citation	Hoffmann, G.,Dulic, M.,Gruic-Sovulj, I.,Palencia, A. The Zn Domain Acts as a Dynamic Switch Coordinating Multiple-Step Aminoacylation in Bacterial Leucyl-tRNA Synthetase Nucleic Acids Res., 2026 Cited by DOI: 10.1093/nar/gkag786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.277 Å)

Structure validation