9TH8

Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA

This is a non-PDB format compatible entry.

Summary for 9TH8

• Entry DOI: 10.2210/pdb9th8/pdb
• EMDB information: 55918
• Descriptor: dsDNA (60-MER), Cell division control protein 45, Mitochondrial morphogenesis protein SLD7, ... (13 entities in total)
• Functional Keywords: helicase, activation, phosphorylation, replication
• Biological source: Saccharomyces cerevisiae; More
• Total number of polymer chains: 17
• Total formula weight: 1435146.17

Authors

Saleh, A.,Noguchi, Y.,Schneider, S.,Aramayo, R.,Speck, C. (deposition date: 2025-12-03, release date: 2026-08-26)

• Primary citation: Noguchi, Y.,Saleh, A.,Schneider, S.,Ivanova, M.E.,Chen, Z.A.,Ranjha, L.,Aramayo, R.,Tognetti, S.,Faull, S.V.,Rappsilber, J.,Speck, C.; Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation; Nat Commun, 2026; DOI: 10.1038/s41467-026-76309-6

Experimental method

ELECTRON MICROSCOPY (2.9 Å)