9TD2

Integrin AlphaIIbBeta3 bound to Fab of the anti-HPA-1a antibody 26.4

Summary for 9TD2

• Entry DOI: 10.2210/pdb9td2/pdb
• EMDB information: 55800
• Descriptor: Integrin alpha-IIb, MAGNESIUM ION, Integrin beta-3, ... (11 entities in total)
• Functional Keywords: human platelet antigen, fnait, alloantibody, cryo-em, cell adhesion
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 242810.79

Authors

de Pereda, J.M.,Stam, W.,Gragera, M.,van der Meer, F.,Chichon, F.J.,Zarkadas, E.,van der Schoot, E.,Vidarsson, G.,Takagi, J.,Margadant, C. (deposition date: 2025-11-22, release date: 2026-06-10)

• Primary citation: de Pereda, J.M.,Stam, W.,Gragera, M.,van der Meer, F.,Chichon, F.J.,Zarkadas, E.,van der Schoot, E.,Vidarsson, G.,Takagi, J.,Margadant, C.; High-resolution cryo-EM structure of integrin aIIbb3 in complex with a disease-causing maternal HPA-1a antibody that blocks integrin activation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.64 Å)