9TD2

Integrin AlphaIIbBeta3 bound to Fab of the anti-HPA-1a antibody 26.4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin alpha-IIb	polymer	993	108456.1	1	UniProt (P08514)	Homo sapiens (human)	GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb
2	B (B)	Integrin beta-3	polymer	735	81402.0	1	UniProt (P05106)	Homo sapiens (human)	Platelet membrane glycoprotein IIIa,GPIIIa
3	C (H)	Antibody 26.4 Fab heavy chain	polymer	242	26033.9	1		Homo sapiens
4	D (L)	Antibody 26.4 Fab light chain	polymer	215	23441.0	1		Homo sapiens
5	E, I (E, I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	F (F)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G48068RF)
7	G, H (G, J)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G62182OO)
8	J, K, L, M, Q... (A, B)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA) PubChem (271)
9	N, O (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG) PubChem (24139)
10	P (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
11	S, T (A, B)	water	water		18.0	9	Chemie (HOH)

Sequence modifications

A: 1 - 963 (UniProt: P08514)

PDB	External Database	Details
Ala 964	-	expression tag
Gln 965	-	expression tag
Cys 966	-	expression tag
Glu 967	-	expression tag
Lys 968	-	expression tag
Glu 969	-	expression tag
Leu 970	-	expression tag
Gln 971	-	expression tag
Ala 972	-	expression tag
Leu 973	-	expression tag
Glu 974	-	expression tag
Lys 975	-	expression tag
Glu 976	-	expression tag
Asn 977	-	expression tag
Ala 978	-	expression tag
Gln 979	-	expression tag
Leu 980	-	expression tag
Glu 981	-	expression tag
Trp 982	-	expression tag
Glu 983	-	expression tag
Leu 984	-	expression tag
Gln 985	-	expression tag
Ala 986	-	expression tag
Leu 987	-	expression tag
Glu 988	-	expression tag
Lys 989	-	expression tag
Glu 990	-	expression tag
Leu 991	-	expression tag
Ala 992	-	expression tag
Gln 993	-	expression tag

B: 1 - 692 (UniProt: P05106)

PDB	External Database	Details
Gly 693	-	expression tag
Gly 694	-	expression tag
Leu 695	-	expression tag
Glu 696	-	expression tag
Asn 697	-	expression tag
Leu 698	-	expression tag
Tyr 699	-	expression tag
Phe 700	-	expression tag
Gln 701	-	expression tag
Gly 702	-	expression tag
Gly 703	-	expression tag
Lys 704	-	expression tag
Asn 705	-	expression tag
Ala 706	-	expression tag
Gln 707	-	expression tag
Cys 708	-	expression tag
Lys 709	-	expression tag
Lys 710	-	expression tag
Lys 711	-	expression tag
Leu 712	-	expression tag
Gln 713	-	expression tag
Ala 714	-	expression tag
Leu 715	-	expression tag
Lys 716	-	expression tag
Lys 717	-	expression tag
Lys 718	-	expression tag
Asn 719	-	expression tag
Ala 720	-	expression tag
Gln 721	-	expression tag
Leu 722	-	expression tag
Lys 723	-	expression tag
Trp 724	-	expression tag
Lys 725	-	expression tag
Leu 726	-	expression tag
Gln 727	-	expression tag
Ala 728	-	expression tag
Leu 729	-	expression tag
Lys 730	-	expression tag
Lys 731	-	expression tag
Lys 732	-	expression tag
Leu 733	-	expression tag
Ala 734	-	expression tag
Gln 735	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	239333.0
Branched	Number of molecules	5
	Total formula weight	2770.6
Non-Polymers*	Number of molecules	9
	Total formula weight	707.2
All*	Total formula weight	242810.8

*Water molecules are not included.