9T8D

Cryo-EM structure of EA-RK-110-bound D3 dopamine receptor

This is a non-PDB format compatible entry.

Summary for 9T8D

• Entry DOI: 10.2210/pdb9t8d/pdb
• EMDB information: 55685
• Descriptor: D(3) dopamine receptor,Soluble cytochrome b562, BAG2 anti-BRIL Fab Heavy chain, BAG2 anti-BRIL Fab Light chain, ... (4 entities in total)
• Functional Keywords: gpcr, inverse-agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 95903.44

Authors

Yardeni, E.H.,Kiss, D.J.,Shavit, K.,Keseru, G.M.,Shalev-Benami, M. (deposition date: 2025-11-12, release date: 2026-09-09)

• Primary citation: Hadas Yardeni, E.,Kiss, D.J.,Sanchez, J.,Shavit, K.,Szepesi Kovacs, D.,Egyed, A.,Vogt, C.D.,Gaitonde, S.A.,Glenn, J.,Canals, M.,Bouvier, M.,Newman, A.H.,Lane, J.R.,Keseru, G.M.,Shalev-Benami, M.; The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology; Sci Adv, 12:-, 2026; DOI: 10.1126/sciadv.aef7411

Experimental method

ELECTRON MICROSCOPY (3.6 Å)