9T8D
Cryo-EM structure of EA-RK-110-bound D3 dopamine receptor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | D(3) dopamine receptor,Soluble cytochrome b562 | polymer | 432 | 47647.8 | 1 | UniProt (P35462) UniProt (P0ABE7) | Homo sapiens (human) | Dopamine D3 receptor,Cytochrome b-562 |
| 2 | B (H) | BAG2 anti-BRIL Fab Heavy chain | polymer | 229 | 24321.1 | 1 | synthetic construct | ||
| 3 | C (L) | BAG2 anti-BRIL Fab Light chain | polymer | 215 | 23483.1 | 1 | synthetic construct | ||
| 4 | D (R) | 3-[4-[2-[4-[3-cyano-5-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea | non-polymer | 451.5 | 1 | Chemie (A1JUJ) |
Sequence modifications
R: 1 - 214 (UniProt: P35462)
R: 1005 - 1109 (UniProt: P0ABE7)
R: 326 - 400 (UniProt: P35462)
| PDB | External Database | Details |
|---|---|---|
| Asp -20 | - | expression tag |
| Tyr -19 | - | expression tag |
| Lys -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Lys -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1011 | Met 29 | engineered mutation |
| Ile 1106 | His 124 | engineered mutation |
| Leu 1110 | - | linker |
| Glu 1111 | - | linker |
| Arg 1112 | - | linker |
| Ala 1113 | - | linker |
| Arg 1114 | - | linker |
| Ser 1115 | - | linker |
| Thr 1116 | - | linker |
| Leu 1117 | - | linker |
| Gln 1118 | - | linker |
| Lys 1119 | - | linker |
| Glu 1120 | - | linker |
| Val 1121 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 1000 | - | linker |
| Arg 1001 | - | linker |
| Arg 1002 | - | linker |
| Gln 1003 | - | linker |
| Leu 1004 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95451.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 451.5 | |
| All* | Total formula weight | 95903.4 |
