9T5P

Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4

Summary for 9T5P

• Entry DOI: 10.2210/pdb9t5p/pdb
• EMDB information: 55592
• Descriptor: Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8D, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: heteromeric lrrc8a-d in complex with sb4, cell swelling, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 7
• Total formula weight: 494037.24

Authors

Lehmann, E.F.,Deneka, D.,Stierli, F.,Rutz, S.,Dutzler, R. (deposition date: 2025-11-05, release date: 2026-09-02)

• Primary citation: Lehmann, E.F.,Deneka, D.,Stierli, F.,Rutz, S.,Dutzler, R.; Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.97 Å)