9T5P
Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Volume-regulated anion channel subunit LRRC8A | polymer | 806 | 93753.9 | 4 | UniProt (Q80WG5) | Mus musculus (house mouse) | Leucine-rich repeat-containing protein 8A,Protein ebouriffe,ebo,Swelling protein 1 |
| 2 | E, F (E, F) | Volume-regulated anion channel subunit LRRC8D | polymer | 458 | 52503.2 | 2 | UniProt (A0A6P5PKE4) | Mus musculus (house mouse) | Leucine-rich repeat-containing protein 5,Leucine-rich repeat-containing protein 8D |
| 3 | G (J) | Volume-regulated anion channel subunit LRRC8D | polymer | 128 | 13891.2 | 1 | Mus musculus (house mouse) | ||
| 4 | H, I (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | synthetic construct |
Sequence modifications
A, B, C, D: 2 - 805 (UniProt: Q80WG5)
E, F: 2 - 456 (UniProt: A0A6P5PKE4)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Leu 61 | Phe 123 | conflict |
| Val 61 | Ala 128 | conflict |
| Val 313 | Leu 314 | conflict |
| Ile 347 | Thr 348 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 493913.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 124.1 | |
| All* | Total formula weight | 494037.2 |
