9T3S

Structure of human HER2 in complex with EPS226 Fab

Summary for 9T3S

• Entry DOI: 10.2210/pdb9t3s/pdb
• EMDB information: 55518
• Descriptor: EPS226 Fab HC, EPS226 Fab LC, Receptor tyrosine-protein kinase erbB-2 (3 entities in total)
• Functional Keywords: antibody fab, complex, cancer, extracellular domain., antitumor protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 121670.60

Authors

Birtley, J.,Regan, L.,Johnson, R.M.,Soni, K.,Pye, V.E.,Fitzgerald, K. (deposition date: 2025-10-29, release date: 2026-03-11)

• Primary citation: Birtley, J.,Johnson, R.M.,Regan, L.,Soni, K.,Pye, V.E.,Fitzgerald, K.; Elucidating the relationship between affinity and potency in the performance of IgE as therapeutic antibodies for cancers with low antigen densities; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)