9T3H

Cryo-EM structure of a human KEOPS sub-complex bound to tRNA

Summary for 9T3H

• Entry DOI: 10.2210/pdb9t3h/pdb
• Related: 9FL9 9T2U
• EMDB information: 55495
• Descriptor: EKC/KEOPS complex subunit TPRKB, EKC/KEOPS complex subunit TP53RK, Probable tRNA N6-adenosine threonylcarbamoyltransferase, ... (4 entities in total)
• Functional Keywords: complex t6a modification trna keops galloway-mowat, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 112563.51

Authors

Cirio, C.,Fernandes, C.A.H.,Venien-Bryan, C.,Collinet, B.,Van Tilbeurgh, H. (deposition date: 2025-10-27, release date: 2026-11-11)

• Primary citation: Cirio, C.,Auxilien, S.,Liger, D.,Fernandes, C.A.H.,Dammak, R.,Zelie, E.,Malhao, M.,Arteni, A.A.,Touboul, D.,Missoury, S.,Arrondel, C.,Mollet, G.,Antignac, C.,Venien-Bryan, C.,van Tilbeurgh, H.,Collinet, B.; Structure of the human KEOPS/tRNA complex: characterization of t6A pathway mutations responsible for the Galloway-Mowat syndrome; To Be Published,

Experimental method

ELECTRON MICROSCOPY (4.22 Å)