9T32

The Cullin 2 RING VHL E3 ligase dimerised by the homoPROTAC CM11

This is a non-PDB format compatible entry.

Summary for 9T32

• Entry DOI: 10.2210/pdb9t32/pdb
• EMDB information: 55480
• Descriptor: Elongin-B, Elongin-C, Cullin-2, ... (6 entities in total)
• Functional Keywords: protac, homoprotac, dimerizer, cm11, vhl, von hippel-lindau, cullin 2, ring, e3, ligase, targeted protein degradation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 252895.38

Authors

Crowe, C.,Ciulli, A. (deposition date: 2025-10-24, release date: 2025-12-03)

• Primary citation: Crowe, C.,Salerno, A.,Sathe, G.,Marsh, G.,Maple, H.,Ciulli, A.; Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes; Biorxiv, 2025; DOI: 10.1101/2025.11.18.689129

Experimental method

ELECTRON MICROSCOPY (6.9 Å)