9T32

The Cullin 2 RING VHL E3 ligase dimerised by the homoPROTAC CM11

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (D, F)	Elongin-B	polymer	103	11619.2	2	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, F (G, J)	Elongin-C	polymer	95	10740.3	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, G (E, I)	Cullin-2	polymer	655	76636.8	2	UniProt (Q13617) Pfam (PF00888) Pfam (PF26557)	Homo sapiens (human)	CUL-2
4	D, H (R, S)	E3 ubiquitin-protein ligase RBX1, N-terminally processed	polymer	89	10526.0	2	UniProt (P62877) Pfam (PF12678)	Homo sapiens (human)	E3 ubiquitin-protein transferase RBX1,N-terminally processed
5	I, J (H, C)	von Hippel-Lindau disease tumor suppressor	polymer	141	16335.6	2	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
6	K (C)	(2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[2-[2-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-2-oxidanylidene-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		1179.4	1	Chemie (A1JTC)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	251715.9
Non-Polymers*	Number of molecules	1
	Total formula weight	1179.4
All*	Total formula weight	252895.4

*Water molecules are not included.