9SQV

Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Composite map)

Summary for 9SQV

Entry DOI	10.2210/pdb9sqv/pdb
EMDB information	55118
Descriptor	Ubiquitin, BRCA1-A complex subunit Abraxas 1, Lys-63-specific deubiquitinase BRCC36, ... (5 entities in total)
Functional Keywords	deubiquitylating enzymes, jamm/mpn family, ubiquitin chains, dna damage repair, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	244878.35
Authors	Foglizzo, M.,Degtjarik, O.,Zeqiraj, E. (deposition date: 2025-09-23, release date: 2026-08-05)
Primary citation	Foglizzo, M.,Datta, A.,Degtjarik, O.,Perera, H.,Liburd, J.,Sykora, U.M.,Ganji, R.S.,Wildsmith, G.,Chandler, F.,Campbell, L.J.,Calabrese, A.N.,Greenberg, R.A.,Zeqiraj, E. Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.21 Å)

Structure validation