9SPS

p53 cancer mutant E285K in complex with DARPin C10-H82R

Summary for 9SPS

• Entry DOI: 10.2210/pdb9sps/pdb
• Descriptor: Cellular tumor antigen p53, DARPin C10-H82R, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: p53, tumor suppressor, cancer mutation, protein stability, protein unfolding disease, designed ankyrin repeat proteins, thermostabilization, mutant p53 reactivation, cancer therapy, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 36491.70

Authors

Mavridi, D.,Yuksel, B.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2025-09-17, release date: 2026-04-22)

• Primary citation: Mavridi, D.,Yuksel, B.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC); p53 cancer mutant E285K in complex with DARPin C10-H82R; to be published,

Experimental method

X-RAY DIFFRACTION (1.42 Å)