9SPN

p53 cancer mutant V157F in complex with DARPin C10

Summary for 9SPN

Entry DOI	10.2210/pdb9spn/pdb
Descriptor	Cellular tumor antigen p53, DARPin C10, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	p53, tumor suppressor, cancer mutation, protein stability, protein unfolding disease, designed ankyrin repeat proteins, thermostabilization, mutant p53 reactivation, cancer therapy, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	36424.57
Authors	Balourdas, D.I.,Muenick, P.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2025-09-17, release date: 2026-04-22)
Primary citation	Balourdas, D.I.,Muenick, P.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC) p53 cancer mutant V157F in complex with DARPin C10 to be published, 1:-,
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation