9SNP

VHL/Elongin B/Elongin C complex with compound 60

This is a non-PDB format compatible entry.

Summary for 9SNP

• Entry DOI: 10.2210/pdb9snp/pdb
• Descriptor: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
• Functional Keywords: e3 ligase, complex, protac, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 168035.96

Authors

Kerry, P.S.,Hole, A.J. (deposition date: 2025-09-11, release date: 2026-04-01)

• Primary citation: Berlin, M.,Cantley, J.,Broccatelli, F.,Cao, L.,Chen, H.,Cheung, T.K.,Crew, A.P.,DiNicola, D.,Dong, H.,Grimmer, M.,Hamman, B.D.,Harbin, A.,He, M.,Hu, X.,Hole, A.J.,Januario, T.,Kerry, P.S.,Liu, X.,Quinn, C.,Rose, C.M.,Rousseau, E.,Snyder, L.B.,Staben, L.R.,Wang, G.,Wang, J.,Ye, X.,Yauch, R.L.,Dragovich, P.S.; Modulation of VHL binding affinity improves selectivity of PROTACs targeting BRM (SMARCA2) over BRG1 (SMARCA4); RESULTS CHEM, 24:103211-, 2026; DOI: 10.1016/j.rechem.2026.103211

Experimental method

X-RAY DIFFRACTION (2.7 Å)