9SI8

Structure of trans-basal conformer of human CBS trapped in PLP-aminoacrylate intermediate state (CBS PLP-AA)- by Helical processing.

Summary for 9SI8

• Entry DOI: 10.2210/pdb9si8/pdb
• EMDB information: 54925
• Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID (3 entities in total)
• Functional Keywords: transsulfuration pathway, l-serine hydro-lyase, heme-binding protein, cbs domain, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 344024.35

Authors

Inayathulla, M.,Tomas, M. (deposition date: 2025-08-28, release date: 2026-07-29)

• Primary citation: Mohammed, I.,Mijatovic, E.,Philipp, T.M.,Janickova, L.,Ascencao, K.,Asturias, F.J.,Martinez-Cruz, L.A.,Szabo, C.,Stahlberg, H.,Majtan, T.; Structural basis for a filamentous morpheein model of human cystathionine beta-synthase; Nat Commun, 2026; DOI: 10.1038/s41467-026-73198-7

Experimental method

ELECTRON MICROSCOPY (2.47 Å)