9SH7

Crystal structure of DENV3 NS5 methyltransferase domain in complex with TO335 inhibitor

This is a non-PDB format compatible entry.

Summary for 9SH7

• Entry DOI: 10.2210/pdb9sh7/pdb
• Descriptor: Genome polyprotein, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[1-[(3-fluorophenyl)methyl]-1,2,3-triazol-4-yl]methyl]amino]-2-azanyl-butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: flavivirus, inhibitor, dengue, methyltransferase, viral protein
• Biological source: dengue virus type 3
• Total number of polymer chains: 2
• Total formula weight: 59570.55

Authors

Krafcikova, P.,Boura, E. (deposition date: 2025-08-25, release date: 2026-09-02)

• Primary citation: Krafcikova, P.,Boura, E.; Crystal structure of DENV3 NS5 methyltransferase domain in complex with TO335 inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)