9S6S

Ternary cryo-EM structure of human ALG9 with Dol25-PP-GlcNAc2Man6, Dol25-P-Man and Fab

This is a non-PDB format compatible entry.

Summary for 9S6S

• Entry DOI: 10.2210/pdb9s6s/pdb
• EMDB information: 54630
• Descriptor: Alpha-1,2-mannosyltransferase ALG9, Hs9-8 Fab heavy chain, Hs9-8 Fab light chain, ... (8 entities in total)
• Functional Keywords: mannosyltransferase, ternary complex, n-linked glycosylation, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 122617.61

Authors

Alexander, J.A.N.,Chen, S.Y.,Mukherjee, S.,de Capitani, M.,Irobalieva, R.N.,Rossi, L.,Agrawal, P.,Kowal, J.,Meirelles, M.A.,Aebi, M.,Reymond, J.L.,Kossiakoff, A.A.,Riniker, S.,Locher, K.P. (deposition date: 2025-08-01, release date: 2026-03-18)

• Primary citation: Alexander, J.A.N.,Chen, S.Y.,Mukherjee, S.,de Capitani, M.,Irobalieva, R.N.,Rossi, L.,Agrawal, P.,Kowal, J.,Meirelles, M.A.,Aebi, M.,Reymond, J.L.,Kossiakoff, A.A.,Riniker, S.,Locher, K.P.; Structural basis for oligomannose N-glycan synthesis in the endoplasmic reticulum; Nat.Chem.Biol., 2026; DOI: 10.1038/s41589-026-02164-7

Experimental method

ELECTRON MICROSCOPY (2.89 Å)