9S3R

Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB

This is a non-PDB format compatible entry.

Summary for 9S3R

• Entry DOI: 10.2210/pdb9s3r/pdb
• EMDB information: 54549
• Descriptor: DNA damage-binding protein 1, DDB1- and CUL4-associated factor 16, Probable global transcription activator SNF2L2, ... (6 entities in total)
• Functional Keywords: protein complex, covalent degrader, targeted protein degradation, transcription, e3 ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 178243.83

Authors

Spiteri, V.A.,Nakasone, M.A.,Casement, R.,Iso, K.,Cowan, A.D.,Ciulli, A. (deposition date: 2025-07-25, release date: 2026-05-20)

• Primary citation: Spiteri, V.A.,Segal, D.,Correa-Saez, A.,Iso, K.,Casement, R.,Munoz i Ordono, M.,Nakasone, M.A.,Sathe, G.,Schatz, C.,Peters, H.,Doward, M.,Kainacher, L.,Cowan, A.D.,Ciulli, A.,Winter, G.E.; Dual E3 ligase recruitment by monovalent degraders enables redundant and tunable degradation of SMARCA2/4.; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.3 Å)