9S3R

Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA damage-binding protein 1	polymer	1140	127097.5	1	UniProt (Q16531)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B (B)	DDB1- and CUL4-associated factor 16	polymer	218	24333.4	1	UniProt (Q9NXF7)	Homo sapiens (human)
3	C (C)	Probable global transcription activator SNF2L2	polymer	123	14380.5	1	UniProt (P51531)	Homo sapiens (human)	ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
4	D (D)	DET1- and DDB1-associated protein 1	polymer	102	11855.3	1	UniProt (Q9BW61)	Homo sapiens (human)	Placenta cross-immune reaction antigen 1,PCIA-1
5	E (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6	F (B)	2-[6-azanyl-5-[(1~{S},5~{R})-8-[2-[(~{E})-3-(azepan-1-yl)prop-1-enyl]pyridin-4-yl]-3,8-diazabicyclo[3.2.1]octan-3-yl]pyridazin-3-yl]phenol	non-polymer		511.7	1	Chemie (A1JLV)

Sequence modifications

B: 1 - 216 (UniProt: Q9NXF7)

PDB	External Database	Details
Gly -1	-	expression tag
Gly 0	-	expression tag

C: 1373 - 1493 (UniProt: P51531)

PDB	External Database	Details
Ser 1371	-	expression tag
Met 1372	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	177666.8
Non-Polymers*	Number of molecules	2
	Total formula weight	577.1
All*	Total formula weight	178243.8

*Water molecules are not included.