9RYL

METTL1 bound to the SAM competitive small molecule inhibitor STM9005

This is a non-PDB format compatible entry.

Summary for 9RYL

• Entry DOI: 10.2210/pdb9ryl/pdb
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase, [(2~{R})-4-(2-azanyl-[1,3]oxazolo[4,5-c]pyridin-7-yl)morpholin-2-yl]-[(1~{S})-6,8-bis(chloranyl)-1-methyl-3,4-dihydro-1~{H}-isoquinolin-2-yl]methanone, SULFATE ION, ... (6 entities in total)
• Functional Keywords: methyl transferase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 27973.18

Authors

Hutchin, A.,McKee, S.T.,Crespillo Torreno, S.,Bowles, L.J.,Frost, L.M.,Brookfield, F.A.,Sapetschnig, A.,Bucknall, S.J.,Thomas, B.,Rausch, O. (deposition date: 2025-07-15, release date: 2026-08-26)

• Primary citation: Yankova, E.,Sapetschnig, A.,Thomas, B.,Evans, S.,Eleftheriou, M.,Fischl, H.,Bucknell, S.,Hutchin, A.,Livi, C.,Azevedo, A.,Webster, N.,Rogan, J.,Russell, J.,Andrews, B.,Weisser, H.,Baxter, J.,Mantica, G.,Lopez-Leon, D.,Tandon, V.,Fosbeary, R.,Gozdecka, M.,Stamou, E.,Vick, B.,Sawyer, S.,Usluer, S.,Joseph, N.,Bejar, M.T.,Rad, R.,Jeremias, I.,Laurenti, E.,Li, J.,Alcolea, M.P.,Adams, D.J.,Vassiliou, G.S.,Khaled, W.T.,Rausch, O.,Tzelepis, K.; Pharmacological inhibition of METTL1 as a novel anti-cancer strategy; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.437 Å)