9RY6

Crystal structure of SARS-CoV-2 NSP3 Macrodomain in complex with SRI1.65 at room temperature

This is a non-PDB format compatible entry.

Summary for 9RY6

• Entry DOI: 10.2210/pdb9ry6/pdb
• Descriptor: Papain-like protease nsp3, ~{N}-[(4-propan-2-ylphenyl)methyl]-7~{H}-pyrrolo[2,3-d]pyrimidine-4-carboxamide (3 entities in total)
• Functional Keywords: room temperature, sars-cov-2, macrodomain, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 18570.12

Authors

Lambert, M.C.,Aledavood, E.,Born, J.,Fairhead, M.,Gil, C.,Koekemoer, L.,Martinez, A.,Mikolajek, H.,Ramos, S.,Sanchez-Weatherby, J.,Sandy, J.,Thompson, A.J.,von Delft, F.,Walsh, M.,Wang, S.,Williams, E.P.,Hough, M.A. (deposition date: 2025-07-14, release date: 2026-07-22)

• Primary citation: Lambert, M.C.,Aledavood, E.,Born, J.,Fairhead, M.,Gil, C.,Martinez, A.,Mikolajek, H.,Sanchez-Weatherby, J.,Ramos, S.,Sandy, J.,Thompson, A.J.,Walsh, M.,Wang, S.,Williams, E.P.,Hough, M.A.; Group deposition of SARS-CoV-2 NSP3 Macrodomain in complex with AI-designed inhibitors from the CIB-CSIC at room temperature; to be published,

Experimental method

X-RAY DIFFRACTION (1.74 Å)