9RXB

VPS34-CII (VPS34/VPS15/BECLIN1/UVRAG) bound to RAB5A (Q79L) on the VPS34 and VPS15 subunits

Summary for 9RXB

• Entry DOI: 10.2210/pdb9rxb/pdb
• EMDB information: 54364
• Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3, GUANOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 4, ... (10 entities in total)
• Functional Keywords: lipid kinase, gtpase, kinase, autophagy, endocytic trafficking, signaling protein, endocytosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 435105.18

Authors

Spokaite, S.,Ohashi, Y.,Dessus, A.N.,Bourguet, M.,Williams, R.L. (deposition date: 2025-07-10, release date: 2026-06-03)

• Primary citation: Spokaite, S.,Ohashi, Y.,Bourguet, M.,Dessus, A.N.,Williams, R.L.; A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution; Elife, 2026; DOI: 10.7554/eLife.110040.3

Experimental method

ELECTRON MICROSCOPY (4.03 Å)