9RXB
VPS34-CII (VPS34/VPS15/BECLIN1/UVRAG) bound to RAB5A (Q79L) on the VPS34 and VPS15 subunits
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 887 | 101680.3 | 1 | UniProt (Q8NEB9) | Homo sapiens (human) | PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34 |
| 2 | B (B) | Phosphoinositide 3-kinase regulatory subunit 4 | polymer | 1370 | 154659.2 | 1 | UniProt (Q99570) | Homo sapiens (human) | PI3-kinase regulatory subunit 4,PI3-kinase p150 subunit,Phosphoinositide 3-kinase adaptor protein |
| 3 | C (C) | Beclin-1 | polymer | 450 | 51953.1 | 1 | UniProt (Q14457) | Homo sapiens (human) | Coiled-coil myosin-like BCL2-interacting protein,Protein GT197 |
| 4 | D (D) | UV radiation resistance associated protein | polymer | 699 | 78289.9 | 1 | UniProt (Q6P1X0) | Homo sapiens (human) | |
| 5 | E, F (E, F) | Ras-related protein Rab-5A | polymer | 212 | 23333.2 | 2 | UniProt (P20339) | Homo sapiens (human) | |
| 6 | G (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 7 | H, K, M (B, E, F) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 8 | I (B) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) | |||
| 9 | J (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 10 | L, N (E, F) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) |
Sequence modifications
B: 2 - 1358 (UniProt: Q99570)
E, F: 1 - 212 (UniProt: P20339)
| PDB | External Database | Details |
|---|---|---|
| Ser 1359 | - | expression tag |
| Arg 1360 | - | expression tag |
| Pro 1361 | - | expression tag |
| Thr 1362 | - | expression tag |
| Thr 1363 | - | expression tag |
| Ala 1364 | - | expression tag |
| Ser 1365 | - | expression tag |
| Glu 1366 | - | expression tag |
| Asn 1367 | - | expression tag |
| Leu 1368 | - | expression tag |
| Tyr 1369 | - | expression tag |
| Phe 1370 | - | expression tag |
| Gln 1371 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 19 | Cys 19 | engineered mutation |
| Ser 63 | Cys 63 | engineered mutation |
| Leu 79 | Gln 79 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 433248.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1856.3 | |
| All* | Total formula weight | 435105.2 |
