9RPP

MeCP2 MBD domain (S134C) in complex with hydroxymethylated CA repeat DNA

Summary for 9RPP

• Entry DOI: 10.2210/pdb9rpp/pdb
• Descriptor: Methyl-CpG-binding protein 2, DNA (5'-D(*TP*CP*TP*GP*CP*AP*CP*AP*(5HC)P*AP*CP*AP*CP*AP*AP*TP*TP*AP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*TP*AP*AP*TP*TP*GP*TP*GP*TP*GP*TP*GP*TP*GP*CP*AP*G)-3'), ... (4 entities in total)
• Functional Keywords: s134c, rett syndrome mutant, mbd, 5-hydroxymethylcytosine, protein dna complex, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 23538.72

Authors

Guggenbuhl, S.,Mohideen Patel, A.K.,Hazemann, I.,Klaholz, B.P. (deposition date: 2025-06-25, release date: 2026-07-08)

• Primary citation: Guggenbuhl, S.,Mohideen Patel, A.K.,Hazemann, I.,Klaholz, B.P.; MeCP2 dysfunction in Rett syndrome mutations is triggered by specificity loss of DNA recognition; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.18 Å)