9RHH

Crystal structure of Kinase domain of HRI kinase

Summary for 9RHH

• Entry DOI: 10.2210/pdb9rhh/pdb
• Descriptor: Eukaryotic translation initiation factor 2-alpha kinase 1, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... (4 entities in total)
• Functional Keywords: integrated stress response, eif2-alpha kinase family, eif2-alpha phosphorylation, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 71301.81

Authors

Rajasekaran, M.B.,Roe, S.M.,Spencer, J. (deposition date: 2025-06-09, release date: 2026-07-15)

• Primary citation: Rajasekaran, M.B.,Booth, J.,Crepin, D.F.,Roe, S.M.,Zhou, L.,Gianga, T.M.,Siligardi, G.,Gonzalez-Mendez, R.,Staikopoulou, M.,Hassan, H.,Oliver, A.,Mancini, E.,Spencer, J.; Structure-function studies of HRIKD-deltaKI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase; Biorxiv, 2026; DOI: 10.64898/2026.07.06.735516

Experimental method

X-RAY DIFFRACTION (2.08 Å)