9RHH
Crystal structure of Kinase domain of HRI kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Eukaryotic translation initiation factor 2-alpha kinase 1 | polymer | 310 | 35445.7 | 2 | UniProt (Q9BQI3) Pfam (PF00069) | Homo sapiens (human) | Heme-controlled repressor,HCR,Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase,Heme-regulated inhibitor,hHRI,Hemin-sensitive initiation factor 2-alpha kinase |
| 2 | C, E, F (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) PubChem (8117) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 244 (UniProt: Q9BQI3)
A, B: 374 - 585 (UniProt: Q9BQI3)
| PDB | External Database | Details |
|---|---|---|
| Gly 149 | - | expression tag |
| Pro 150 | - | expression tag |
| Leu 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
| Met 154 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 372 | - | linker |
| Ser 373 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70891.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 410.5 | |
| All* | Total formula weight | 71301.8 |
