9RF2

M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF5

Summary for 9RF2

Entry DOI	10.2210/pdb9rf2/pdb
Descriptor	Monoacylglycerol lipase, [1-[6-[(4-methoxyphenyl)amino]pyrimidin-4-yl]pyrazol-4-yl]-[(3S)-3-oxidanylpyrrolidin-1-yl]methanone, [1-[6-[(4-methoxyphenyl)amino]pyrimidin-4-yl]pyrazol-4-yl]-[(3R)-3-oxidanylpyrrolidin-1-yl]methanone, ... (5 entities in total)
Functional Keywords	rv0183, inhibitor, monoacylglycerol lipase, hydrolase
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	1
Total formula weight	34414.30
Authors	Riegler-Berket, L.,Goedl, L.,Oberer, M.,Polidori, N. (deposition date: 2025-06-04, release date: 2025-08-13, Last modification date: 2025-10-29)
Primary citation	Riegler-Berket, L.,Godl, L.,Polidori, N.,Aschauer, P.,Grininger, C.,Prosser, G.,Lichtenegger, J.,Sagmeister, T.,Parigger, L.,Gruber, C.C.,Reiling, N.,Oberer, M. M. tuberculosis meets European lead factory:Identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography Disease and Therapeutics, 1:100002-, 2025 Cited by DOI: 10.1016/j.dist.2025.100002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation