9R27

Regorafenib in complex with p38alpha (MAPK14)

This is a non-PDB format compatible entry.

Summary for 9R27

• Entry DOI: 10.2210/pdb9r27/pdb
• Descriptor: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 4-[4-[[4-chloranyl-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluoranyl-phenoxy]-~{N}-methyl-pyridine-2-carboxamide (3 entities in total)
• Functional Keywords: kinase, inhibitor, approved, matched molecular pair, mmp, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42118.38

Authors

Gomez, S.M.,Buehrmann, M.,Klein, A.,Vasa, S.K.,Weisner, J.,Vatheuer, H.,Czodrowski, P.,Rauh, D.,Linser, R. (deposition date: 2025-04-29, release date: 2026-05-06)

• Primary citation: Gomez, S.M.,Buehrmann, M.,Klein, A.,Vasa, S.K.,Weisner, J.,Vatheuer, H.,Czodrowski, P.,Rauh, D.,Linser, R.; Sorafenib and regorafenib differentially impact the dynamic conformational ensemble of p38alpha; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)