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9QE5

VCB in complex with VHL-binding compound 82

This is a non-PDB format compatible entry.
Summary for 9QE5
Entry DOI10.2210/pdb9qe5/pdb
Related9QE4
DescriptorElongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywordsprotac, degrader, complex, e3 ligase, vhl, vcb, ligase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains12
Total formula weight198139.53
Authors
Braun, M.B.,Dierlamm, N.,Hartmann, M.D. (deposition date: 2025-03-07, release date: 2025-04-23)
Primary citationWittenburg, S.,Zuleeg, M.R.,Peter, K.,Lemnitzer, P.,Voget, R.,Bricelj, A.,Gobec, M.,Dierlamm, N.,Braun, M.B.,Geiger, T.M.,Heim, C.,Stakemeier, A.,Wagner, K.G.,Nowak, R.P.,Hartmann, M.D.,Sosic, I.,Guetschow, M.,Kroenke, J.,Steinebach, C.
Breaking Barriers in PROTAC Design: Improving Solubility of USP7-Targeting Degraders
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

243083

数据于2025-10-15公开中

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