9QE5

VCB in complex with VHL-binding compound 82

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Elongin-B	polymer	129	14914.8	4	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E, H, K (B, E, H, K)	Elongin-C	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F, I, L (C, F, I, L)	von Hippel-Lindau disease tumor suppressor	polymer	203	23116.9	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
4	M, N, O, P (C, F, I, L)	(2~{S},4~{R})-1-[(2~{S})-1-(1-fluoranylcyclopropyl)carbonylpiperidin-2-yl]carbonyl-~{N}-[(1~{S})-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		528.6	4	Chemie (A1I58)
5	Q, R, S (A, G, J)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, D, G, J: 1 - 104 (UniProt: Q15370)

PDB	External Database	Details
Met -24	-	initiating methionine
Lys -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Met -15	-	expression tag
Ser -14	-	expression tag
Asp -13	-	expression tag
Tyr -12	-	expression tag
Asp -11	-	expression tag
Ile -10	-	expression tag
Pro -9	-	expression tag
Thr -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

B, E, H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

C, F, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 11	-	initiating methionine
Ala 12	-	expression tag
Ser 13	-	expression tag
Ala 14	-	expression tag
Trp 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
Pro 18	-	expression tag
Gln 19	-	expression tag
Phe 20	-	expression tag
Glu 21	-	expression tag
Lys 22	-	expression tag
Gly 23	-	expression tag
Gly 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
Gly 27	-	expression tag
Gly 28	-	expression tag
Gly 29	-	expression tag
Ser 30	-	expression tag
Gly 31	-	expression tag
Gly 32	-	expression tag
Ser 33	-	expression tag
Ala 34	-	expression tag
Trp 35	-	expression tag
Ser 36	-	expression tag
His 37	-	expression tag
Pro 38	-	expression tag
Gln 39	-	expression tag
Phe 40	-	expression tag
Glu 41	-	expression tag
Lys 42	-	expression tag
Ser 43	-	expression tag
Gly 44	-	expression tag
Glu 45	-	expression tag
Asn 46	-	expression tag
Leu 47	-	expression tag
Tyr 48	-	expression tag
Phe 49	-	expression tag
Gln 50	-	expression tag
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	196025.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2114.6
All*	Total formula weight	198139.5

*Water molecules are not included.