9QD4

Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist cp30a

This is a non-PDB format compatible entry.

Summary for 9QD4

• Entry DOI: 10.2210/pdb9qd4/pdb
• Descriptor: Neurotensin receptor type 1, DARPin fusion, (2~{S})-4-methyl-2-[[3-[5-(2-methylphenyl)-1,2,3,4-tetrazol-1-yl]-5-(5-methylthiophen-2-yl)phenyl]carbonylamino]pentanoic acid (2 entities in total)
• Functional Keywords: g protein-coupled receptor, neurotensin receptor, full agonist, small-molecule complex, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 1
• Total formula weight: 55488.85

Authors

Deluigi, M.,Hilge, M.,Plueckthun, A. (deposition date: 2025-03-06, release date: 2026-02-11)

• Primary citation: Panel, N.,Duc Vo, D.,Huebner, H.,Deluigi, M.,Pach, S.,Belair, F.,Weikert, D.,Klenk, C.,Hilge, M.,Brochu, I.,Longpre, J.M.,Hu, H.,Kapla, J.,Kampen, S.,Sarret, P.,Plueckthun, A.,Kihlberg, J.,Gmeiner, P.,Carlsson, J.; Structure-guided design of small-molecule agonists for neurotensin receptors identifies nonopioid analgesics; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.112 Å)