9QD4

Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist cp30a

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Neurotensin receptor type 1, DARPin fusion	polymer	500	54999.3	1	UniProt (P20789) Pfam (PF00001)	Rattus norvegicus (Norway rat)	NT-R-1,NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH
2	B (A)	(2~{S})-4-methyl-2-[[3-[5-(2-methylphenyl)-1,2,3,4-tetrazol-1-yl]-5-(5-methylthiophen-2-yl)phenyl]carbonylamino]pentanoic acid	non-polymer		489.6	1	Chemie (A1I5W)

Sequence modifications

A: 50 - 371 (UniProt: P20789)

PDB	External Database	Details
Gly 46	-	expression tag
Pro 47	-	expression tag
Gly 48	-	expression tag
Ser 49	-	expression tag
Gly 83	Ser 83	engineered mutation
Leu 86	Ala 86	engineered mutation
Arg 101	Thr 101	engineered mutation
Asp 103	His 103	engineered mutation
Tyr 105	His 105	engineered mutation
Phe 119	Leu 119	engineered mutation
Leu 121	Met 121	engineered mutation
Asp 124	Glu 124	engineered mutation
Lys 143	Arg 143	engineered mutation
Glu 150	Asp 150	engineered mutation
Val 161	Ala 161	engineered mutation
Leu 167	Arg 167	engineered mutation
Leu 213	Arg 213	engineered mutation
Leu 234	Val 234	engineered mutation
Arg 235	Lys 235	engineered mutation
Leu 240	Val 240	engineered mutation
Ala 253	Ile 253	engineered mutation
Ala 260	Ile 260	engineered mutation
Arg 262	Asn 262	engineered mutation
Arg 263	Lys 263	engineered mutation
Arg 305	His 305	engineered mutation
Val 332	Cys 332	engineered mutation
Ala 342	Phe 342	engineered mutation
Ser 354	Thr 354	engineered mutation
Val 358	Phe 358	engineered mutation
Ala 362	Ser 362	engineered mutation

A: 372 - 545 (PDB: 9QD4)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54999.3
Non-Polymers*	Number of molecules	1
	Total formula weight	489.6
All*	Total formula weight	55488.9

*Water molecules are not included.