9QBU

Crystal structure of WRN in complex with (S)-27 (GSK5819992)

This is a non-PDB format compatible entry.

Summary for 9QBU

• Entry DOI: 10.2210/pdb9qbu/pdb
• Descriptor: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, 1-[(2~{S})-2-(2-azaspiro[3.3]heptan-2-ylcarbonyl)-4-[2-[4-(trifluoromethyl)phenyl]ethanoyl]piperazin-1-yl]propan-1-one, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: helicase, wrn, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 102119.73

Authors

Chaikuad, A.,Chung, C.-W. (deposition date: 2025-03-03, release date: 2026-03-11)

• Primary citation: Chaikuad, A.,Chung, C.-W.; Crystal structure of WRN in complex with (S)-27 (GSK5819992); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)