9QBU

Crystal structure of WRN in complex with (S)-27 (GSK5819992)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	polymer	443	50480.9	2	UniProt (Q14191)	Homo sapiens (human)	DNA helicase,RecQ-like type 3,RecQ protein-like 2,Werner syndrome protein
2	C, F (A, B)	1-[(2~{S})-2-(2-azaspiro[3.3]heptan-2-ylcarbonyl)-4-[2-[4-(trifluoromethyl)phenyl]ethanoyl]piperazin-1-yl]propan-1-one	non-polymer		451.5	2	Chemie (A1I5L)
3	D, G (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	E, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	I, J (A, B)	water	water		18.0	178	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	100961.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1157.9
All*	Total formula weight	102119.7

*Water molecules are not included.