9QA5

Structure of the N-SH2 domain of SHP2 in complex with the phosphoY627-Gab1 (613-651) peptide

Summary for 9QA5

Entry DOI	10.2210/pdb9qa5/pdb
Descriptor	Isoform 3 of Tyrosine-protein phosphatase non-receptor type 11, GRB2-associated-binding protein 1 (3 entities in total)
Functional Keywords	sh2-domain, phosphatase, ptpn11, phospho-tyrosine, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	16230.06
Authors	Machner, L.,Breithaupt, C.,Kniest, J.,Parthier, C.,Feller, S.M.,Stubbs, M.T. (deposition date: 2025-02-27, release date: 2025-12-31)
Primary citation	Machner, L.,Shaikhqasem, A.,Gruber, T.,Hamdi, F.,Breithaupt, C.,Kniest, J.,Wiebe, F.,Lewitzky, M.,Parthier, C.,Kyrilis, F.L.,Balbach, J.,Kastritis, P.L.,Feller, S.M.,Stubbs, M.T. Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1 Structure, 2025 Cited by DOI: 10.1016/j.str.2025.11.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation