9Q6F

Structure of Plasmodium falciparum 20S proteasome bound to an asparagine-ethylenediamine based inhibitor TDI6245

This is a non-PDB format compatible entry.

Summary for 9Q6F

• Entry DOI: 10.2210/pdb9q6f/pdb
• EMDB information: 72277
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta, N~4~-tert-butyl-N~2~-(4-methylbenzene-1-sulfonyl)-N~1~-[2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-L-aspartamide, ... (15 entities in total)
• Functional Keywords: plasmodium falciparum antimalarial proteasome inhibitors, hydrolase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 28
• Total formula weight: 771459.49

Authors

Hsu, H.C.,Li, H. (deposition date: 2025-08-22, release date: 2026-07-29)

• Primary citation: Zhang, H.,Hsu, H.C.,Zhan, W.,Hara, R.,Visone, J.,Imaeda, T.,Okamoto, R.,Fajtova, P.,Sato, K.,Michino, M.,Garg, S.,Kreutzfeld, O.,Tumwebaze, P.,Orena, S.,Okitwi, M.,Aso, K.,Cooper, R.,Rosenthal, P.J.,Meinke, P.T.,Foley, M.,ODonoghue, A.J.,Li, H.,Kirkman, L.A.,Lin, G.; Structure-activity relationship study of antimalarial asparagine derived proteasome inhibitors; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.86 Å)