9Q6F

Structure of Plasmodium falciparum 20S proteasome bound to an asparagine-ethylenediamine based inhibitor TDI6245

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O (A, O)	Proteasome subunit alpha type-6	polymer	260	29531.7	2	UniProt (W7JVP8)	Plasmodium falciparum (malaria parasite P. falciparum)
2	B, P (B, P)	Proteasome subunit alpha type-2	polymer	235	26556.4	2	UniProt (A0A2I0BQ13)	Plasmodium falciparum (malaria parasite P. falciparum)
3	C, Q (C, Q)	Proteasome subunit alpha type	polymer	246	27977.7	2	UniProt (W7KN95)	Plasmodium falciparum (malaria parasite P. falciparum)
4	D, R (D, R)	Proteasome subunit alpha type	polymer	241	27263.3	2	UniProt (A0A2I0BS43)	Plasmodium falciparum (malaria parasite P. falciparum)
5	E, S (E, S)	Proteasome subunit alpha type	polymer	256	28417.4	2	UniProt (A0A2I0BP34)	Plasmodium falciparum (malaria parasite P. falciparum)
6	F, T (F, T)	Proteasome subunit alpha type-1	polymer	253	28742.6	2	UniProt (W7K5W7)	Plasmodium falciparum (malaria parasite P. falciparum)
7	G, U (G, U)	Proteasome subunit alpha type-3	polymer	252	29324.3	2	UniProt (W7K040)	Plasmodium falciparum (malaria parasite P. falciparum)
8	H, V (H, V)	Proteasome subunit beta type-6	polymer	252	29143.9	2	UniProt (W7JUG8)	Plasmodium falciparum (malaria parasite P. falciparum)
9	I, W (I, W)	Proteasome subunit beta	polymer	229	25104.9	2	UniProt (W7K1J4)	Plasmodium falciparum (malaria parasite P. falciparum)
10	J, X (J, X)	Proteasome subunit beta	polymer	218	24533.1	2	UniProt (A0A2I0BXS0)	Plasmodium falciparum (malaria parasite P. falciparum)
11	K, Y (K, Y)	Proteasome subunit beta	polymer	195	22889.1	2	UniProt (W7JKG5)	Plasmodium falciparum (malaria parasite P. falciparum)
12	L, Z (L, Z)	Proteasome subunit beta	polymer	211	23620.6	2	UniProt (W7K6A8)	Plasmodium falciparum (malaria parasite P. falciparum)
13	AA, M (M, a)	Proteasome subunit beta	polymer	240	27301.2	2	UniProt (A0A2I0BU46)	Plasmodium falciparum (malaria parasite P. falciparum)
14	BA, N (N, b)	Proteasome subunit beta	polymer	302	34823.0	2	UniProt (W7K6I2)	Plasmodium falciparum (malaria parasite P. falciparum)
15	CA, DA (L, Z)	N~4~-tert-butyl-N~2~-(4-methylbenzene-1-sulfonyl)-N~1~-[2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-L-aspartamide	non-polymer		500.6	2	Chemie (A1CRS)

Sequence modifications

N, b: 1 - 265 (UniProt: W7K6I2)

PDB	External Database	Details
Glu 266	-	expression tag
Asn 267	-	expression tag
Leu 268	-	expression tag
Tyr 269	-	expression tag
Phe 270	-	expression tag
Gln 271	-	expression tag
Ser 272	-	expression tag
Ser 273	-	expression tag
Ala 274	-	expression tag
Trp 275	-	expression tag
Ser 276	-	expression tag
His 277	-	expression tag
Pro 278	-	expression tag
Gln 279	-	expression tag
Phe 280	-	expression tag
Glu 281	-	expression tag
Lys 282	-	expression tag
Gly 283	-	expression tag
Gly 284	-	expression tag
Gly 285	-	expression tag
Ser 286	-	expression tag
Gly 287	-	expression tag
Gly 288	-	expression tag
Gly 289	-	expression tag
Ser 290	-	expression tag
Gly 291	-	expression tag
Gly 292	-	expression tag
Ser 293	-	expression tag
Ala 294	-	expression tag
Trp 295	-	expression tag
Ser 296	-	expression tag
His 297	-	expression tag
Pro 298	-	expression tag
Gln 299	-	expression tag
Phe 300	-	expression tag
Glu 301	-	expression tag
Lys 302	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	770458.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1001.2
All*	Total formula weight	771459.5

*Water molecules are not included.