9Q60

CryoEM Structure of human MDA5 disease-linked mutant T331I with dsRNA (one protein subunit on dsRNA)

Summary for 9Q60

• Entry DOI: 10.2210/pdb9q60/pdb
• EMDB information: 72244
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA-13mer, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: rlr, mda5, mda5 disease-linked mutant, t331i, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 92560.32

Authors

Xu, L.,Chung, K.,Pyle, A. (deposition date: 2025-08-21, release date: 2026-09-16)

• Primary citation: Xu, L.,Chung, K.,Guo, R.,Pan, A.,Pyle, A.M.; Unraveling the molecular basis for MDA5 T331I disease-linked mutation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.12 Å)