9Q60
CryoEM Structure of human MDA5 disease-linked mutant T331I with dsRNA (one protein subunit on dsRNA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Interferon-induced helicase C domain-containing protein 1 | polymer | 728 | 83714.5 | 1 | UniProt (Q9BYX4) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) | Homo sapiens (human) | Clinically amyopathic dermatomyositis autoantigen 140 kDa,CADM-140 autoantigen,Helicase with 2 CARD domains,Helicard,Interferon-induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,Murabutide down-regulated protein,RIG-I-like receptor 2,RLR-2,RNA helicase-DEAD box protein 116 |
| 2 | B (B) | RNA-13mer | polymer | 13 | 4213.6 | 1 | synthetic construct | ||
| 3 | C (A) | RNA-13mer | polymer | 13 | 4076.5 | 1 | synthetic construct | ||
| 4 | D, E (C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | F (C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 6 | G (C) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
C: 298 - 1025 (UniProt: Q9BYX4)
| PDB | External Database | Details |
|---|---|---|
| Ile 331 | Thr 331 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 92004.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 555.8 | |
| All* | Total formula weight | 92560.3 |
