9Q5W

CryoEM Structure of human MDA5 T331I mutant in complex with dsRNA

Summary for 9Q5W

• Entry DOI: 10.2210/pdb9q5w/pdb
• EMDB information: 72243
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (29-MER), ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: rlr, mda5, filament, t331i disease-linked mutant, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 186974.40

Authors

Xu, L.,Chung, K.,Pyle, A. (deposition date: 2025-08-21, release date: 2026-09-16)

• Primary citation: Xu, L.,Chung, K.,Guo, R.,Pan, A.,Pyle, A.M.; Unraveling the molecular basis for MDA5 T331I disease-linked mutation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.21 Å)