9Q5W
CryoEM Structure of human MDA5 T331I mutant in complex with dsRNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (C, I) | Interferon-induced helicase C domain-containing protein 1 | polymer | 728 | 83714.5 | 2 | UniProt (Q9BYX4) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) | Homo sapiens (human) | Clinically amyopathic dermatomyositis autoantigen 140 kDa,CADM-140 autoantigen,Helicase with 2 CARD domains,Helicard,Interferon-induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,Murabutide down-regulated protein,RIG-I-like receptor 2,RLR-2,RNA helicase-DEAD box protein 116 |
| 2 | B (B) | RNA (29-MER) | polymer | 29 | 9359.5 | 1 | synthetic construct | ||
| 3 | C (A) | RNA (29-MER) | polymer | 29 | 9171.5 | 1 | synthetic construct | ||
| 4 | E, F (C, I) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence modifications
C, I: 298 - 1025 (UniProt: Q9BYX4)
| PDB | External Database | Details |
|---|---|---|
| Ile 331 | Thr 331 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 185960.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1014.4 | |
| All* | Total formula weight | 186974.4 |
