9Q0F

Structure of angiotensin II type 1 receptor bound to a b-arrestin biased allosteric modulator stabilized by a synthetic nanobody

This is a non-PDB format compatible entry.

Summary for 9Q0F

• Entry DOI: 10.2210/pdb9q0f/pdb
• Related: 9W7R
• EMDB information: 65731 72097
• Descriptor: Type-1 angiotensin II receptor, TRV023, Nanobody NB.AT110i1, ... (5 entities in total)
• Functional Keywords: angiotensin ii type 1 receptor, at1r, g protein-coupled receptor, gpcr, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 59161.37

Authors

Liu, S.,Peng, X.,Pakharukova, N.,Ahn, S.,Lefkowitz, R.J. (deposition date: 2025-08-12, release date: 2026-08-26)

• Primary citation: Liu, S.,Xiao, P.,Elgeti, M.,Fine, E.J.,Lucero, E.Y.,Vestergaard, M.,Wang, J.,Jyothidasan, A.,Angus, L.,Qu, C.,Olsen, E.,Mazis, G.,Madsen, J.K.,Suomivuori, C.-M.,Kim, J.,Pakharukova, N.,Rahman, R.,Kereliuk, S.M.,Koch, W.,Strachan, R.T.,Staus, D.P.,Masoudi, A.,Hubbell, W.L.,Kahsai, A.W.,Dror, R.O.,Rockman, H.A.,Sun, J.-P.,Ahn, S.,Lefkowitz, R.J.; Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.02 Å)