9Q0F
Structure of angiotensin II type 1 receptor bound to a b-arrestin biased allosteric modulator stabilized by a synthetic nanobody
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Type-1 angiotensin II receptor | polymer | 366 | 41968.7 | 1 | UniProt (P30556) | Homo sapiens (human) | AT1AR,AT1BR,Angiotensin II type-1 receptor,AT1 receptor |
| 2 | B (B) | TRV023 | polymer | 8 | 944.1 | 1 | synthetic construct | ||
| 3 | C (D) | Nanobody NB.AT110i1 | polymer | 134 | 14783.1 | 1 | synthetic construct | ||
| 4 | D, E (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (5997) | |||
| 5 | F (A) | (7P)-N-[(1R)-3-amino-1-(6-methoxypyridin-3-yl)-3-oxopropyl]-7-(3-chlorophenyl)-5,6-dimethyl-4-(3-{[2-(trifluoromethyl)phenyl]methyl}azetidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-2-carboxamide | non-polymer | 692.1 | 1 | Chemie (A1CNF) |
Sequence modifications
A: 2 - 359 (UniProt: P30556)
| PDB | External Database | Details |
|---|---|---|
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57695.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1465.4 | |
| All* | Total formula weight | 59161.4 |
