9PPL

Structure of STING in complex with MK-2118

This is a non-PDB format compatible entry.

Summary for 9PPL

• Entry DOI: 10.2210/pdb9ppl/pdb
• Descriptor: Stimulator of interferon genes protein, (2S)-4-(5,6-dimethoxy-1-benzothiophen-2-yl)-2-methyl-4-oxobutanoic acid (3 entities in total)
• Functional Keywords: sting, mk-2118, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 21863.54

Authors

Lesburg, C.A.,Henderson, T.,Ho, T.,Hayes, R.P.,Bennett, J. (deposition date: 2025-07-21, release date: 2026-07-01)

• Primary citation: Henderson, T.,Altman, M.D.,Buevich, A.V.,Cash, B.,Cemerski, S.,Chang, W.,Chen, Y.,Childers, M.,Cumming, J.,Dandliker, P.J.,Feng, G.,Haidle, A.,Hayes, R.P.,Ho, T.,Jewell, J.P.,Kariv, I.,Knemeyer, I.,Kopinja, J.,Lacey, B.M.,Laskey, J.,Lesburg, C.A.,Liang, R.,Lim, J.,Long, B.J.,Lu, M.,Ma, Y.,Minnihan, E.C.,Otte, R.D.,O’Donnell, G.,Pan, B.S.,Perera, S.A.,Piesvaux, J.A.,Presland, J.P.,Price, L.,Rakhilina, L.,Sauvagnat, B.,Schroeder, G.K.,Sharma, S.,Trotter, B.W.,Tyagarajan, S.,Woo, H.,Wyss, D.F.,Xu, S.,Addona, G.H.,Bennett, D.J.; Discovery of MK-2118, a Small-Molecule Agonist of STING; Acs Med.Chem.Lett., 2026; DOI: 10.1021/acsmedchemlett.5c00540

Experimental method

X-RAY DIFFRACTION (2.01 Å)