9PPL

Structure of STING in complex with MK-2118

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Stimulator of interferon genes protein	polymer	188	21555.2	1	UniProt (Q86WV6) Pfam (PF15009)	Homo sapiens (human)	hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173
2	B (A)	(2S)-4-(5,6-dimethoxy-1-benzothiophen-2-yl)-2-methyl-4-oxobutanoic acid	non-polymer		308.4	1	Chemie (A1CIY)
3	C (A)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

A: 154 - 341 (UniProt: Q86WV6)

PDB	External Database	Details
Ala 230	Gly 230	conflict
Arg 232	His 232	variant
Gln 293	Arg 293	variant

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21555.2
Non-Polymers*	Number of molecules	1
	Total formula weight	308.4
All*	Total formula weight	21863.5

*Water molecules are not included.