9PNC

Crystal structure of human mitochondrial ClpP protease C144R mutant in complex with imipridone compound, TR-65

Summary for 9PNC

• Entry DOI: 10.2210/pdb9pnc/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, 3-{[(10R)-4-[(4-chlorophenyl)methyl]-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl]methyl}benzonitrile (3 entities in total)
• Functional Keywords: proteolysis, mitochondria, perrault syndrome, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 14
• Total formula weight: 345321.80

Authors

Mabanglo, M.F.,Houry, W.A. (deposition date: 2025-07-19, release date: 2026-07-22)

• Primary citation: Houry, W.A.,Mabanglo, M.F.; A molecular basis for Perrault syndrome type 3 and the identification of novel substrates of the mitochondrial ClpXP protease; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)