9PNC
Crystal structure of human mitochondrial ClpP protease C144R mutant in complex with imipridone compound, TR-65
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease proteolytic subunit, mitochondrial | polymer | 221 | 24233.9 | 14 | UniProt (Q16740) Pfam (PF00574) | Homo sapiens (human) | Caseinolytic mitochondrial matrix peptidase proteolytic subunit,Endopeptidase Clp |
| 2 | AA, BA, O, P, Q... (M, N, A, B, C...) | 3-{[(10R)-4-[(4-chlorophenyl)methyl]-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl]methyl}benzonitrile | non-polymer | 431.9 | 14 | Chemie (PJF) PubChem (139034884) | |||
| 3 | CA, DA, EA, FA, GA... (A, B, C, D, E...) | water | water | 18.0 | 242 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N: 58 - 277 (UniProt: Q16740)
| PDB | External Database | Details |
|---|---|---|
| Ser 57 | - | expression tag |
| Arg 144 | Cys 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 339275.0 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 6046.8 | |
| All* | Total formula weight | 345321.8 |
